Before using of Duphaston 10 mg
Irregular duration of menstrual cycles and irregular duration and occurrence of periods, which caused by deficiency of progesterone. Combined with an estrogenic substance, Duphaston 10 mg may be applied in dysfunctional uterine bleeding, secondary amenorrhoea and post-menopausal complaints where endogenous deficiency of progesterone is implicated.
Directions In general
The dosage of Directions medication schemes below are meant as general recommendations. For optimum therapeutic effect, the dosages of Directions medicine are to be adapted to the severity and nature of the disease.
In irregular menstrual cycles due to endogenous deficiency of progesterone
Duphaston 10 mg medicinal agent 5 mg to 10 mg is recommended specially in irregular menstrual cycles due to shortened luteal phase (that is a pre-menopause). Treatment should be repeated for some cycles.
Administration of Duphaston 10mg in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Duphaston 10 mg is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle.
In dysfunctional uterine bleeding
The symptomatic treatment is directed at stopping the bleeding, including a subsequent withdrawal bleeding.
To stop bleeding: 0,10 mg ethinylestradiol together with Duphaston 10 mg twice daily for five to seven days.
To avert heavy bleedings: Duphaston 5 mg twice a day from day 11 to day 25 of the menstrual cycle, if necessary, combined with an estrogen within the first half of the menstrual cycle.
If for the treatment of post-menopausal complaints estrogens are used (called hormone replacement therapy), Duphaston 10 mg is taken to counteract the effects of unopposed estrogens on the endometrium. A following withdrawal bleeding is induced.If on cyclic estrogen therapy: Duphaston 10 mg twice a day within the last 12 to 14 days of the treatment female patients.
Duphaston 10 mg medicine should not be given to female patients with a history of thromboembolic disorders nor to those withundiagnosed vaginal bleeding.
Duphaston 10 mg should be taken with caution in female patients with cardiovascular, diabetes mellitus, renal or hepatic impairment, migraine, asthma and epilepsy. It should be taken with care in people with a history of mental depression. Keep in a dark and dry place at temperatures not exceeding 25 C. You should to store in a place inaccessible to your children.
Possible side effects of Duphaston
Side effects of Duphaston 10 mg medication may include allergic skin rashes or urticaria, gastro-intestinal disturbances, fluid retention, changes in libido, acne, mental depression, mass gain and breast changes, which may comprise gynaecomastia or discomfort. Alterations in tests of liver function have been reported, less frequently jaundice.
In a small per cent of the treated cases, breakthrough bleeding can happen, which may be averted by increasing the dose. During the clinical application of Duphaston 10 mg, no side effects were observed. If you take too much for more full information about any other probable risks associated with this medication, read the information provided with the medicine or consult your personal doctor or pharmacist.
Drug interactions may result in unwanted by-effects or avert a medication from doing its job. Several medicinal agents or medical conditions can interact with this medication. You should inform your pharmacist or doctor of all prescription and over-the-counter medication that you are using.
What is the shelf life of the tablets?
The expiry date is mentioned on every blister. It's different for various batches. The shelf life is two years from the date of manufacture and this date would differ from batch to batch depending on when these drugs were manufactured.